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KMID : 0376619940190040213
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Seoul Journal of Psychiatry
1994 Volume.19 No. 4 p.213 ~ p.223
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Dopamine Receptors: New Subtypes
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Abstract
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Dopamine receptors in the central nervous system play an important role in the pathophysiology and treatment of psychoses and movement disorders. Until recently only two dopamine receptor subtypes(D1 : and D2) were thought to exist. Five
different
dopamine receptors now been cloned and identified using molecular biological techniques. Based on their structural, pharmacological and functional similarities, these may be classified into D1-like(D1, D5) and D2-like(D2, D3 D4) subfamilies. D2R
was
previously thought as the main target in actions of antipsychotics and pathophysiology of schizophrenia, but this hypothesis has to be reexamined in the light of recent findings. The author reviewed the molecular characteristics of recently
cloned
dopamine receptor subtypes and discussed prospects for their clinical applications.
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KEYWORD
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